J Abnorm Psychol. Computerized screening of comorbidity in adolescents with substance or psychiatric disorders. 2020 Apr;129(3):293-304. doi: 10.1037/abn0000502. Mean Total and Distress Prodromal Questionnaire–Brief Child Version (PQ-BC) Scores for Family History of…, NLM The Adolescent Brain and Cognitive Development (ABCD) Study is supported by awards U01DA041022, U01DA041025, U01DA041028, U01DA041048, U01DA041089, U01DA041093, U01DA041106, U01DA041117, U01DA041120, U01DA041134, U01DA041148, U01DA041156, U01DA041174, U24DA041123, and U24DA041147 from the NIH and additional federal partners (https://abcdstudy.org/federal-partners.html). Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort. Importance:  T, Bucholz In this validation study of 3984 children aged 9 to 10 years, the instrument demonstrated adequate internal reliability and measurement invariance across race/ethnicity and sex. Prodromal questionnaire to assess prodromal symptoms filled by the young person as a self report General Assessment Scale for Social Functioning (GASC) [ Time Frame: Baseline and 18 months ] General Assessment Scale for Social Functioning assesses patients general functioning filled … The Total score is the sum of endorsed questions (0 indicates no; 1, yes; possible scores range from 0 to 21). Associations Between Prenatal Cannabis Exposure and Childhood Outcomes: Results From the ABCD Study. Model Estimates for Neuropsychological Test Performance, Table 4. Clipboard, Search History, and several other advanced features are temporarily unavailable.  S, Burgess Childhood motor coordination and adult schizophrenia spectrum disorders.  H, Nishimura  S, Kaneko Lee KW, Chan KW, Chang WC, Lee EH, Hui CL, Chen EY. This study also replicated the associations between PLEs and internalizing symptoms,16,27,28,31,32,37 supporting evidence that affective dysregulation occurs across the psychosis risk continuum.61 Although externalizing symptoms were associated with PLEs,29,31 associations between child-rated internalizing symptoms and PLEs were significantly stronger. Disclaimer: This report reflects the views of the authors and may not reflect the opinions or views of the NIH or the ABCD consortium investigators.  I, Cannon  N, Nelson-Gray No other disclosures were reported.  J, Rawdon A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings. Primary Sidebar. Anxiety and depression symptoms in psychometrically identified schizotypy.  M, Ellman PQ-BC, Prodromal Questionnaire–Brief Child Version.  SK, Owoso This site needs JavaScript to work properly. Again, family history of psychosis continued to be associated with PQ-BC scores, even with the developmental delays in the same model (eTable 6 in the Supplement). 2020 Sep 23:e202902. Objective:To examine the construct validity and psychometric properties of a measure of PLEs, the Prodromal Questionnaire-Brief Child Version (PQ-BC). Assessment of the Prodromal Questionnaire–Brief Child Version for Measurement of Self-reported Psychoticlike Experiences in Childhood. Acquisition, analysis, or interpretation of data: Karcher, Barch, Savill, Huber, Simon, Sher, Loewy.  JM, Cullen Original and Modified Versions of Questions and Prevalence of Endorsement, eTable 3.  KE, Barrantes-Vidal  A.  Cognitive development prior to onset of psychosis.  S, Blailes We measured PLEs45,46 using (1) a parent-rated child PLE measure created from 4 items from the Child Behavior Checklist (CBCL) (eMethods in the Supplement)46-49 and (2) a summation of parent-rated KSADS current psychotic symptoms (a child-rated psychosis module was not administered).42,43 Last, a family history of psychosis, depression, and mania in first-degree relatives was assessed using the parent-rated Family History Assessment Module Screener,50 with each diagnosis scored as present or absent.  et al.  R, Customize your JAMA Network experience by selecting one or more topics from the list below. Get the latest public health information from CDC: https://www.coronavirus.gov. Mayo Higher ratings of current child clumsiness were also significantly associated with greater PQ-BC scores (Total score: β = 0.055 [95% CI, 0.026-0.084]; Distress score: β = 0.055 [95% CI, 0.025-0.085]).  J, Reininghaus Higher PQ-BC scores were associated with greater scores on the child-rated KSADS internalizing symptom composite (Total score: β = 0.311 [95% CI, 0.283-0.339]; Distress score: β = 0.353 [95% CI, 0.325-0.381]), and although child-rated UPPS-P-CSF symptoms were associated with PQ-BC scores (β range, 0.031 [95% CI, 0.004-0.059] to 0.151 [95% CI, 0.122-0.179]), the internalizing composite had a significantly greater association with PQ-BC scores than did externalizing symptoms (z>−6.66; P < .001). Girls had lower PQ-BC Total scores (2.400 [0.215] vs 2.727 [0.214]; β = −0.092; 95% CI, −0.152 to −0.032), but there was no significant association of sex with PQ-BC Distress scores. Kessler  TD. 2021 Jan;46(1):131-142. doi: 10.1038/s41386-020-0736-6. The fluid composite consists of Flanker Inhibitory Control and Attention, List Sorting Working Memory, Dimensional Change Card Sort, Pattern Comparison Processing Speed, and Picture Sequence Memory.  S. Fitting linear mixed-effects models using lme4.  W.  Prevalence, impact and cultural context of psychotic experiences among ethnic minority youth.  S.  Psychotic-like experiences and other antecedents of schizophrenia in children aged 9-12 years: a comparison of ethnic and migrant groups in the United Kingdom. The study analyses included 3984 participants (1885 girls [47.3%] and 2099 boys [52.7%]; mean [SE] age, 10.0 [0.01] years).  SM, Similar associations were observed with greater CBCL parent-rated child PLEs and PQ-BC Total (β = 0.083; 95% CI, 0.054-0.113) and Distress (β = 0.082; 95% CI, 0.053-0.112) scores.  JP, Reich  et al; Brain Development Cooperative Group. JAMA Psychiatry. Participants completed all National Institutes of Health Toolbox Cognitive Battery (NIHTB-CB) tests.51,52 The NIHTB-CB consists of 7 tests, grouped into 2 composite scores. We next examined whether race/ethnicity or sex showed mean level differences on PQ-BC scores (Table 2).  EA. PLEs were found to be significantly associated with measures of urbanicity, safety, and crime.  C, Sample Characteristics for Included vs Missing Participants, eTable 2. The speech delays composite was coded as the summation of a delay in speaking a first word and parent-rated concern regarding speech development (eMethods in the Supplement). Barragan  A, Martin All parents provided written informed consent and all children provided assent.  J, Williams Conflict of Interest Disclosures: Dr Barch reported consulting for Pfizer, Inc. Dr Simon reported being chief executive officer of Cognivive, Inc, a digital neurotherapeutics company (there was no overlap between the content of this report and the company’s business interests). Lancefield  TV,  R, Harrington  JY, McKenzie McAusland Question Is the Prodromal Questionnaire–Brief Child Version a valid measure of psychoticlike experiences in childhood?  L.  A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder. Furthermore, the choice to read questions to participants to ensure comprehension may have influenced disclosure willingness for some individuals. Is the Prodromal Questionnaire–Brief Child Version a valid measure of psychoticlike experiences in childhood? Model Estimates for Motor and Speech Developmental Milestones.  A, Tanii 2020.  N, Harley The final sample size was 3984 individuals. Change in fit from the metric to scalar invariance model also passed invariance criteria for both PQ-BC scores, suggesting similar mean PQ-BC response profiles across groups.  K, Avenevoli  D, Corey Epub 2020 Jun 15. Furthermore, these data suggest that PLEs at school age are associated with many of the same familial, cognitive, and emotional factors associated with psychotic symptoms in older populations, consistent with the dimensionality of psychosis across the lifespan. Karcher NR, Loewy RL, Savill M, Avenevoli S, Huber RS, Simon TJ, Leckliter IN, Sher KJ, Barch DM. The study analyses included 3984 participants (1885 girls [47.3%] and 2099 boys [52.7%]; mean [SE] age, 10.0 [0.01] years).  |   M, Zammit Question  Get the latest research from NIH: https://www.nih.gov/coronavirus.  MB, Verhulst  et al.  M, Zhang  J.  RJ, van Os  SS, Heaton Stronger associations between PQ-BC scores and internalizing symptoms may indicate some overlap between these constructs, consistent with research indicating the experience of PLEs as concerning and worrying.3,62 Furthermore, conceptual similarity exists between internalizing symptoms and negative symptoms (ie, social withdrawal, affective flattening, and avolition), which are associated with psychosis risk.63, Despite the wealth of research indicating that cognitive deficits exist before the onset of psychosis (including in childhood),11,37,64-66 research regarding the impaired cognitive domains associated with childhood PLEs is relatively scarce.16,36 The present study found that PQ-BC scores were associated with deficits in fluid and crystalized IQ, but with greater evidence that impairments in some domains (eg, working memory) were associated with higher PQ-BC scores.  S, Clarke 2016 Feb;10(1):3-16. doi: 10.1111/eip.12228.  SA, Murray Lower performance on List Sorting Working Memory was associated with higher PQ-BC Total (β = −0.042; 95% CI, −0.077 to −0.008) and Distress (β = −0.051; 95% CI, −0.086 to −0.017) scores.  KR, Hobbs  LM, Ngiralmau Seidman A socio-demographic questionnaire, the Prodromal Questionnaire-Brief Version (PQ-B) and the Strengths and Difficulties Questionnaire (SDQ) were administered to each student.  et al. Assessment of the Prodromal Questionnaire-Brief Child Version for Measurement of Self-reported Psychoticlike Experiences in Childhood.  KR, Cullen O'Brien KJ, Barch DM, Kandala S, Karcher NR.  M, Murray Hothorn  MC,  TR. This validation study used data from the first wave of the Adolescent Brain and Cognitive Development (ABCD) Study, a prospective longitudinal study aimed at assessing risk factors associated with adverse physical and mental health outcomes from ages 9 to 10 years into late adolescence and early adulthood. All Rights Reserved.  U.  Psychosis as a transdiagnostic and extended phenotype in the general population. Lower performance on the Pattern Comparison Processing Speed and Oral Reading Recognition was also associated with higher Total scores (β =  −0.041 [95% CI, −0.074 to −0.008] and β = −0.043 [95% CI, −0.080 to −0.007], respectively) (see eResults in the Supplement).  FF.  et al. ABCD consortium investigators designed and implemented the study and/or provided data but did not necessarily participate in analysis or writing of this report.  |  Please enable it to take advantage of the complete set of features!  T.  Hallucinatory experiences in a community sample of Japanese children. Bates Prodromal Questionnaire–Brief Child Version, Internalizing and Externalizing Symptom Measures, Associations With Internalizing and Externalizing Symptoms.  ML, Taylor This model passed all criteria to indicate strict invariance (ie, similar loadings, thresholds, and unique/residual variance across boys and girls), suggesting that both PQ-BC scores measure the same construct across sex.  B, Brent 2018;75(8):853–861.  S.  Racism, psychosis and common mental disorder among ethnic minority groups in England.  HJ, Maeda Albaugh  S, Walters  D, Luking  A, al.  RM, Rutter The 16-item Version of the Prodromal Questionnaire (PQ-16) If TRUE: how much distress did you experience? The present study is the first, to our knowledge, to examine the validity (ie, measurement invariance and construct validity) of the PQ-BC by using data collected from the Adolescent Brain and Cognitive Development (ABCD) study (https://abcdstudy.org). Laurens Childhood psychoticlike experiences (PLEs) are associated with greater odds of a diagnosis of a psychotic disorder during adulthood.  CJ, Stanger  J, Birmaher  MB. To examine the construct validity and psychometric properties of a measure of PLEs, the Prodromal Questionnaire–Brief Child Version (PQ-BC). Starkowska A, Tyburski E, Kucharska-Mazur J, Mak M, Samochowiec J. In this validation study of 3984 children aged 9 to 10 years, the instrument demonstrated adequate internal reliability and measurement invariance across race/ethnicity and sex.  JE. Role of the Funder/Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Figure.. Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort. Hierarchical linear models analyzed the associations between PQ-BC scores and (1) race/ethnicity (white, African American, Hispanic, or other); (2) sex; (3) family history of psychosis, depression, or mania; (4) other PLEs (ie, KSADS psychotic symptom domain and CBCL parent-rated child PLEs); (5) internalizing symptoms (ie, KSADS symptom domains and internalizing composite; comparable results are obtained using the CBCL internalizing measure47) and the UPPS-P-CSF child-rated externalizing symptoms (analyses were also conducted using the parent-rated KSADS and CBCL externalizing measures42,43,47) (eMethods in the Supplement); (6) neuropsychological test performance (crystallized or fluid intelligence NIHTB-CB composites, then individual NIHTB-CB tests to examine the independent contributions of each test); and (7) motor and speech developmental milestone delays (as composites then individually to examine the independent contributions of each milestone).  GL. Epub 2015 Mar 15.  LM. Participants completed the PQ-BC,14 a 21-item self-report questionnaire, modified for use with children aged 9 to 10 years based on a series of interviews assessing children’s understanding of the items (eMethods and eTable 2 in the Supplement), with a visual response scale included as a Distress scale (eFigure in the Supplement).41 Consistent with previous research,14,17 Total and Distress scores were calculated.  R, Wittchen  IM, Our website uses cookies to enhance your experience. Kaufman  D, Ferdinand Family history of depression was not significantly associated with PQ-BC Total (2.798 [0.121]; β = 0.022; 95% CI, −0.010 to 0.055) or Distress (6.536 [0.360]; β = 0.032 95% CI, −0.001 to 0.064) scores; similar findings applied to a family history of mania for the PQ-BC Total (3.102 [0.248]; β = 0.004; 95% CI, −0.029 to 0.036) and Distress (7.152 [0.735]; β = 0.014; 95% CI, −0.017 to 0.046) scores (these results remained consistent when the depression and mania groups excluded individuals with a family history of psychosis) (Figure and eTable 4 in the Supplement). These results provide support for the construct validity and demonstrate adequate psychometric properties of a self-report instrument designed to measure childhood PLEs, providing evidence that the PQ-BC may be a useful measure of early risk for psychotic … The cognition battery of the NIH Toolbox for Assessment of Neurological and Behavioral Function: validation in an adult sample. Karcher NR, Barch DM, Avenevoli S, Savill M, Huber RS, Simon TJ, Leckliter IN, Sher KJ, Loewy RL .  NR, Slutske  S, Albaugh  J, Adverse childhood experiences and psychotic-like experiences are associated above and beyond shared correlates: Findings from the adolescent brain cognitive development study. Table 1 displays the results of the stepwise invariance tests comparing the race/ethnicity groups for the PQ-BC Total and Distress scores.  P, Abbott The results demonstrated measurement invariance across race/ethnicity and sex. Cannon  et al. Objective   TE,  M.  Psychotic-like experiences in the general population: characterizing a high-risk group for psychosis.  K, Banerjea  MC, Murphy Addington Laurens See this image and copyright information in PMC. 2014 Feb;152(2-3):498-502. doi: 10.1016/j.schres.2013.12.012. Lewandowski As reported in Table 4, delays in both motor and speech developmental milestones were associated with higher PQ-BC Total (β = 0.057 [95% CI, 0.026-0.086] for motor; β = 0.042 [95% CI, 0.010-0.073] for speech) and Distress (β = 0.048 [95% CI, 0.017-0.079] for motor; β = 0.049 [95% CI, 0.018-0.081] for speech) scores. Main Outcomes and Measures   P, Krabbendam J Abnorm Psychol. The association between changes in depression/anxiety and trajectories of psychotic-like experiences over a year in adolescence  [published online October 18, 2017].  TE, Cannon A family history of psychotic disorder was associated with higher mean (SE) PQ-BC Total (3.883 [0.352]; β = 0.061; 95% CI, 0.027-0.094) and Distress (10.210 [1.043]; β = 0.051; 95% CI, 0.018-0.084) scores, whereas a family history of depression or mania was not. Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychoses: the New York High-Risk Project. Is the Prodromal Questionnaire–Brief Child Version a valid measure of psychoticlike experiences in childhood? Published Online: June 6, 2018. doi:10.1001/jamapsychiatry.2018.1334.  TV, Ducharme Erlenmeyer-Kimling Revising the BIS/BAS Scale to study development: measurement invariance and normative effects of age and sex from childhood through adulthood.  L,  KS, Raudino An item response theory analysis of the Prodromal Questionnaire-Brief Child Version: Developing a screening form that informs understanding of self-reported psychotic-like experiences in childhood.  M, Lieb  MJ, Sunderland  et al.  MD, Wichers  S, Kelly Income to needs is defined as the ratio of family income to the appropriate poverty threshold.  RO, Clancy Biol Psychiatry Cogn Neurosci Neuroimaging.  et al. Higher PQ-BC scores were associated with higher rates of child-rated internalizing symptoms (Total score: β range, 0.218 [95% CI, 0.189-0.246] to 0.273 [95% CI, 0.245-0.301]; Distress score: β range, 0.248 [95% CI, 0.220-0.277] to 0.310 [95% CI, 0.281-0.338]), neuropsychological test performance deficits such as working memory (Total score: β = −0.042 [95% CI, −0.077 to −0.008]; Distress score: β = −0.051 [95% CI, −0.086 to −0.017]), and motor and speech developmental milestone delays (Total score: β = 0.057 [95% CI, 0.026-0.086] for motor; β = 0.042 [95% CI, 0.010-0.073] for speech; Distress score: β = 0.048 [95% CI, 0.017-0.079] for motor; β = 0.049 [95% CI, 0.018-0.081] for speech).  M.  Neurocognitive performance of a community-based sample of young people at putative ultra high risk for psychosis: support for the processing speed hypothesis.  MD, Avenevoli None of these contributors were compensated for this work. Age-related volumetric change of limbic structures and subclinical anxious/depressed symptomatology in typically developing children and adolescents. The results are compatible with findings that working memory impairments are associated with psychosis risk and early psychotic symptoms in adolescence.34,36,67 Consistent with previous research,34 the results showed some support for deficits in reading and processing speed being related to psychosis risk.  AE, Barragan The PQ-BC Total and Distress scores were analyzed for measurement invariance across race/ethnicity and sex, their associations with measures of PLEs, and their associations with known correlates of PLEs, including internalizing and externalizing symptoms, neuropsychological test performance, and developmental milestones.